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KMID : 0355620200460020099
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2020 Volume.46 No. 2 p.99 ~ p.107
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Analyzing the factors that influence occult metastasis in oral tongue cancer
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Shin Jung-Hyun
Yoon Hye-Jung
Kim Soung-Min
Lee Jong-Ho
Myoung Hoon
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Abstract
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Objectives: We accessed the various clinico-histopathological factors, and their association with occult metastasis (OM) in oral tongue squamous cell carcinoma (OTSCC).
Materials and Methods: One hundred-nine patients with OTSCC were divided into the elective neck dissection (END) group and the watchful waiting (WW) group. Age, sex, T-stage, depth of invasion and differentiation were evaluated to determine the correlation between clinico-histopathological factors and OM. For immunohistochemical analysis, paraffin-embedded blocks of 41 OTSCC specimens were examined with antibodies (VEGF-c, c-Met, and ROR1).
Results: The group with tumor thickness of oral tongue cancer ≥3 mm had higher incidence of OM than those with a thickness of <3 mm. The depth of invasion was statistically correlated with OM (P=0.022). Immunohistochemical analysis showed that high expression of VEGF-c (P=0.043), c-Met (P=0.009), and ROR-1 (P=0.003) were statistically correlated with OM.
Conclusion: The analysis of these clinico-histopathological and immunohistochemical factors can help to determine neck dissection in clinically negative (cN0) patients.
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KEYWORD
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Tongue cancer, Elective neck dissection, Watchful waiting, Occult metastasis, Immunohistochemistry
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